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ASK1Apoptosis Signal-Regulating Kinase 1
ASK1Arabidopsis Serine/Threonine Kinase1
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TRAF2: TNF receptor-associated factor 2; ASK1: apoptosis signal-regulating kinase 1; JNK: c-Jun N-terminal kinase; ATF4: activating transcription factor 4.
Inoshita et al., "Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation," Journal of Biological Chemistry, vol.
Expression miRNA change Function References miR-34 * Downregulation Increase of XIAP involved in [99] resistance to apoptosis miR-203 Upregulation Increase of MMP-1 involved [100] in extracellular matrix degradation Increase of IL-6 involved in inflammation miR-155 Upregulation Decrease of MMP-3 involved [101] in extracellular matrix degradation miR-155 Upregulation Decrease of IKBKE involved [102] in inflammation miR-22 Downregulation Increase of CYR61 involved [103] in cell proliferation and Th17 cell differentiation miR-20a Downregulation Increase of ASK1 involved in [104] TLR4 pathway miR-19b Downregulation Increase of TLR2 involved in [105] innate immunity
Ichijo, "Oxidative stress-induced diseases via the ASK1 signaling pathway," International Journal of Cell Biology, vol.
IRE1 interacts with the TNF receptor-associated factor (TRAF) 2; in turn, the complex of IRE1 and TRAF2 are associated with apoptosis signal-regulating kinase 1 (ASK1), which activates both the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPK) [35, 36].
Jo, "Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis," Biochemical and Biophysical Research Communications, vol.
CCN2 can increase the production of IL-1[beta] in osteoarthritis synovial fibroblasts through generation of [[alpha].sub.v][[beta].sub.3]/[[alpha].sub.v][[beta].sub.5] integrin-dependent ROS and subsequent activation of signal regulating kinase 1 (ASK1), p38/JNK, and NF-[kappa]B signaling pathways.
Our results demonstrated that psoralen enhanced the proliferation of osteoblast and blocked the apoptosis of osteoblast by modulating inositol-requiring enzyme 1 (IRE1)/apoptosis signaling kinase 1 (ASK1)/c-jun N-terminal kinase (JNK) pathway.
Two main operator consoles (ASK1, ASK2) contain control processors, keyboards, control and display.
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
(1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.