AT-1RAngiotensin II Type 1 Receptor (gene)
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ARR: Aldosterone renin ratio AT-1R: Angiotensin II type I receptor BMI: Body mass index CT: Computed tomogram IHA: Idiopathic hyperaldosteronism HU: Hounsfield Units PA: Primary hyperaldosteronism TRAb: Thyroid stimulating hormone receptor antibodies TNF [alpha]: Tumor necrosis factor alpha TSH: Thyroid stimulating hormone.
During the fibrotic process, Ang II combines with AT-1R, which can interact with G-proteins such as RhoA.
Changes in Expression of AT-1R, TGF-[beta]1, p22-phox, and p47-phox in Kidney Tissue in Mice after Different Treatment.
AT-1R, the important receptor of Ang II, has been shown to play a significant role in increasing the urinary protein level [32].
Other possible mechanisms of EGCG such as function as an AT-1R blocker should be explored in further studies.