AT1-R

AcronymDefinition
AT1-RAngiotensin II type 1-Receptor
AT1-RAngiotensin II Type 1-Receptors
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References in periodicals archive ?
Effect of Renal Denervation, Central Blockade of AT1-R, or Inhibition of TNF-[alpha] on ISO-Induced Protein Expressions of ACE and TNF-[alpha] in the Brain.
The major findings of the present study are as follows: (1) RD significantly inhibited the decrease in BP in the development of ISO-induced HF and favorably altered autonomic regulation, including increase in HR variability and BRS and decrease in BP variability; (2) RD significantly inhibited ISO-induced increases in mRNA and protein expression of RAS components and PICs in the LT and PVN, two forebrain nuclei involved in regulation of BP and sympathetic activity; (3) central blockade of either AT1-R or TNF-[alpha] partially mimicked the beneficial actions of RD in the ISO-induced HF.
This depressor effect was attenuated by bilateral RD, but not by intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe) or TNF-[alpha] inhibitor etanercept (ENT) (a).
Caption: Figure 4: Tachycardiac effects induced by isoproterenol (ISO) in rats with sham surgery (Sham), renal denervation (RD), intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe), or TNF-[alpha] inhibitor etanercept (ENT) (a).
Caption: Figure 5: Spectral analysis of pulse interval (PI) variability, mean arterial pressure (MAP) variability, and spontaneous baroreflex sensitivity (SBRS) in rats with sham surgery (Sham), renal denervation (RD), intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe), or TNF-[alpha] inhibitor etanercept (ENT) during saline or isoproterenol (ISO) administration.
Caption: Figure 6: Comparison of decreases in heart rate (HR (a)) to increases in mean arterial pressure (MAP) evoked by phenylephrine (PE) in rats with sham surgery (Sham), renal denervation (RD), intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe), or TNF-[alpha] inhibitor etanercept (ENT) after saline or isoproterenol (ISO) administration.
Caption: Figure 7: Quantitative comparison of the mRNA expression of renin-angiotensin system components and proinflammatory cytokines in the lamina terminalis (LT (a)) and paraventricular nucleus (PVN (b)) of rats receiving renal denervation (RD), intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe), or TNF-[alpha] inhibitor etanercept (ENT) after isoproterenol (ISO) administration (n = 6/group; ([section]) P < 0.05 versus Sham + saline; * P < 0.05 versus Sham + saline or RD + saline; (#) P < 0.05 versus Sham + ISO).