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(Note that, in this study, the levels of RAS components were not compared between STZ eNOS -/- and eNOS +/+ mice.) In db/db eNOS -/- and db/db kidneys, RAS components were changed in the following manner compared with nondiabetic mice: (upregulated) angiotensinogen mRNA, (downregulated) renin and ACE1 mRNA, and (unaltered) ACE2 and Ang II receptors (AT1a, AT1b
, AT2, and Mas).