AT2RAngiotensin II Type 2 Receptor
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Previous studies showed that different polymorphisms in AT1R and AT2R gens have various effects on hypertension (15, 16).
The processes are mediated by the activation of receptors belonging to the RAAS among which are the family of Ang receptors (ATjR, AT2R, AT4R, and AT7R), the prorenin receptor, the MAS receptor (MASR), and the MET (METR) receptor; the last of which has an activity mediated by the insulin-regulated aminopeptidase receptor (IRAP) [52, 53].
Pulakat, "Differential effects of [beta]-blockers, Angiotensin II receptor blockers, and a novel AT2R agonist NP6A4 on stress response of nutrient-starved cardiovascular cells," PLoS ONE, vol.
In addition, western blotting revealed that local expression of AT1R in SHR was significantly higher compared to WKY (Figure 5(c), P < 0.001), whereas AT2R was markedly decreased (Figure 5(d), P < 0.001).
The following genes had significant association with diabetic nephropathy: eNOS, AT2R, SUMO4, IL-10, VEGF, MTHFR, ACE, and VDR.
Synthesized Ang II within the cell binds to intracellular and/or nuclear AT1R, AT2R, or Mas receptors and activates downstream signalling pathways.
Classically, angiotensin II (Ang II) mediates its action via the Ang II type 1 (AT1R) and type 2 (AT2R) receptors.
Deparaffinized tissue sections were processed for immunohistochemistry as described elsewhere [16] using primary antibodies to AT1R (Santa Cruz Biotechnology, TX, USA), AT2R (Novus Biologicals, CO, USA), MasR (Novus Biologicals, CO, USA), 8-hydroxy-2'deoxyguanosine (8-OHdG, Japan Institute for the Control of Aging, Shizuoka, Japan), and 3-nitrotyrosine (Santa Cruz Biotechnology, TX, USA).
suggests that the chronic antihypertensive and anti-inflammatory effects of Compound 21 (a selective angiotensin type 2 receptor (AT2R) agonist) in DOCA/NaCl-induced female hypertensive rats may function through female sex hormones.
Several components of the RAS were analyzed including renin, prorenin receptor (PRR), angiotensinogen (AGT), angiotensin-converting enzyme (ACE), ACE2, angiotensin II type 1 (AT1R) and 2 receptor (AT2R), and angiotensin (1-7) MAS receptor.