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ATF1Activation Transcription Factor 1
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Based on the results seen in Dow Coming's DoE testing, a new Gen 3 fluorosilicone compound was formulated to provide long-term property retention when exposed to today's most widely used ATFs: Mercon LV, ATF+4, Dexron VI and Pentosin ATF1.
4 (1) ATF exposure and volume swell tested to ASTM D471 (2) Durometer tested per ASTM D2240 (3) Tensile strength, elongation and modulus tested to ASTM D412 Table 4 - comparative test data for Gen 1, Gen 2 and Gen 3 FSRs exposed to ATFs at 150[degrees]C Gen 1 FSR in ATFs Properties, A changes Mercon ATF+4 Dexron Pentosin LV VI ATF1 Control data: FSR compound properties Durometer hardness (2), durometer A 54 54 54 54 Tensile strength3, MPa 11 11 11 11 Elongation (3), % 475 475 475 475 100% modulus (3), MPa 2.
Yeast that lack the ATF1 gene, which encodes an enzyme that produces the fruity aroma chemicals, grow just fine in the lab, says geneticist Kevin Verstrepen of the University of Leuven and VIB, a research institute also in Belgium.
40) Occasional cases with EWSR1 rearrangement have failed to show involvement of ATF1 or CREB1, suggesting that these may have as yet unidentified fusion partners.
Since this assay does not provide information regarding the translocation partner, additional FISH studies were performed, which showed rearrangement of the ATF1 locus on 12q13 (Figure 3, B).
However in contrast to MM, CCSTA is characterized by the t(12;22)(q13;q12) that leads to the fusion of the ATF1 gene localized to 12q13 to the EWSR1 gene at 22q12 in up to 90% of cases.