revealed that selenium supplementation during pregnancy and postpartum period inhibits progress of Hashimoto's thyroiditis and results in decreased ATPO
titers and improved ultrasound thyroid echogenicity.
For most cohort members, TSH, ATPO, free thyroxine ([FT.sub.4]), and autoantibodies to thyroglobulin (ATG) were measured in serum samples with LUMitest immunochemiluminescence assays (BRAHMS Diagnostica GmbH, Henningsdorf, Germany) using a Berthold 953 luminometer (Berthold Technologies, GmbH & Co.
Elevated levels of ATPO (ATPO-positivity) and ATG (ATG positivity) were defined as ATPO > 60 U/mL and ATG > 60 U/mL, respectively, consistent with BRAHMS recommendation.
The background adjustment factors were outcome-specific and included sex, age at examination (10-14, 15-19, 20-24, [greater than or equal to] 25 years), oblast (an administrative subdivision similar to a state or province) of residency at examination, rural or urban residency at examination, self-reported current cigarette smoking, self-reported current vitamin consumption, self-reported history of any thyroid disease in parents or siblings, year and season of examination, level of urinary iodine (< 20, 20-49, 50-99, [greater than or equal to] 100 [micro]g/L, or unknown), presence of diffuse goiter based on thyroid palpation, ATPO and ATG concentrations ([less than or equal to] 60, > 60 U/mL).
The comparison of patients with solitary or multiple nodules showed that age (46.0 vs 49.2 p=0.268), FT4 (3.53 vs 3.72 ng/dL p=0.677), FT3 (7.87 vs 8.52 pg/mL p=0.609), TSH (0.035 vs 0.015 mIU/mL p=0.399), ATPO (382.5 vs 327.7 p=0.550), ATG (240.0 vs 384.3 p=0.271), and radioactive iodine uptake did not differ between groups.
In logistic regression analysis, adjusting for age, gender, FT4, FT3, TRAb, ATPO, ATG, thyroid volume, 4-hour and 24-hour RAI uptake, we demonstrated that age (OR:6.867, p=0.009) was the significant independent variable predicting nodular GD (Table 2).
Hormone levels were analyzed by immunoradiometric assay for TSH and radioimmunoassay for FT4 and ATPO using commercial reagent kits of the IZO-TOP (Hungary).
Serum concentrations of TSH and ATPO were similar in both genders, whereas mean levels of FT4 were higher in men than in women.
For each cross-classification cell, the number of observed thyroid cancers, PY, and PY-weighted means for continuous variables at the first screening examination (including TSH, ATPO
, TG, thyroid volume, and urinary iodine) were computed.