Detection of ATRX
and IDH1-R132H immunohistochemistry in the progression of 211 paired gliomas.
profiled the genetic features of multifocal GBM and found that M-GBMs had no IDH1, ATRX
, or PDGFRA mutations, significantly associated with the mesenchymal subtype.
Two other commonly mutated genes, DAXX and ATRX
, which had not previously been linked to cancer, also have epigenetic effects on how DNA is read.
In 2003, we described (1) a broad-range denaturing gradient gel electrophoresis method for mutation scanning of the entire open reading frame and canonical splice sites of the ATRX
gene (OMIM 300032), a zinc finger transcriptional regulator undergoing X inactivation and probably involved in chromatin remodeling, DNA methylation, and gene expression in mammalian development (2,3).
Tickers featured: ALKS, ATRX
, DRRX, INHL, JNJ, PFE/AVE, SNY.
Jordy is one of only 12 people in the world suffering from ATRX
syndrome which causes cerebral palsy.
This laboratory-developed NGS test protocol is based on a well-validated research use-only kit that targets 54 genes, including all exons of 15 genes (BCOR, BCORL1, CDKN2A, CEBPA, CUX1, DNMT3A, ETV6, EZH2, IKZF1, KDM6A, PHF6, RAD21, RUNX1, STAG2, and ZRSR2) and hot spot exons/regions of 39 genes (ABL1, ASXL1, ATRX
, BRAF, CALR, CBL, CBLB, CBLC, CSF3R, FBXW7, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, JAK2, JAK3, KIT, KMT2A/MLL, KRAS, MPL, MYD88, NOTCH1, NPM1, NRAS, PDGFRA, PTEN, PTPN11, SETBP1, SF3B1, SMC1A, SMC3, SRSF2, TET2, TP53, U2AF1, and WT1).
87) DAXX and ATRX
loss is associated with increased metastasis and shorter survival in PanNETs but has not been identified in PanNECs.
Tickers featured: ADRX, AGN, APPX, ATRX
, AZN, BGEN, BMY, BRL, BVF, CNCT, DNA, ELN, ENZN, FHRX, FRX, GSK, IMCL, ISPH, JNJ, KG, KV, MRX, MYL, NOVN, NVAX, PFE, PHA, SEPR, SGP, SHPGY, SKYE, TARO, TEVA, WFHC, WYE.
111 NaPro Biotherapeutics NPRO 112 Oralabs Holding Corp.
6,13) IDH-mutant astrocytomas also tend to show inactivating alterations in TP53 and ATRX
, findings that can assist in their molecular diagnosis as well.
Tickers featured: ADRX, ALKS, ARDM, ATRX
, BJCT, BVF, CHIR, CIMA, COB, ELN, EMIS, ENDP, ENZN, FRX, GSK, INHL, JNJ, KVA, MATX, NOVN, NSTK, NVAX, NVS, PFE, PPCO, SKYE, WPI.