By incorporating (MIC90 = 1.5ug/mL) of amoxicillin, the determined values of AUIC were 13.2 and 14.3 hours in Lohi sheep and Beetal goats respectively.
It is speculated that these dosage regimens might achieve the desired value of AUIC = 125 hours; predictor of antibacterial activity.
where SE is the static effort; AURC is the area under real curve; AUIC
is the area under ideal curve; [AURC.sub.4-24] is calculated in the time window 4-24 seconds excluding the initial transient period 0-4 seconds.
These patients had a lower maximum concentration ([C.sub.max]), AUIC (0-ro), and higher Vd (26.8 L v.
Their conclusion was that higher AUIC ratios may be necessary to achieve clinical cure in hospital-acquired pneumonia.
With regard to the concentration-dependent antibiotics, optimising the AUIC of fluoroquinolones reduced the development of resistance and was more likely to eradicate the pathogen.
(2002), In support of user interface design in the rational unified process, in 'AUIC
'02: Proceedings of the Third Australasian conference on User interfaces', Australian Computer Society, Inc., Darlinghurst, Australia, Australia, pp.
Both T>MIC and AUIC
values are directly dependent on the MIC value, and dosing should be optimised according to these values.
Cmax/MIC and AUIC are highest for ciprofloxacin against P aeruginosa; against S.
Comparison of pharmacokinetic and pharmacodynamic parameters for four fluoroquinolones and selected bacterial species (a) Fluoroquinolone Dose (mg) Cmax (a,b) [AUC.sub.24] (b) (mg/L) (mg x h/L) Ciprofloxacin 500 3.0 28 750 3.6 32 Levofloxacin 500 5.7 48 Moxifloxacin 400 4.5 48 Gatifloxacin 400 4.2 34 Streptococcus pneumoniae Fluoroquinolone MIC (c) Cmax:MIC AUIC Ciprofloxacin 2 1.5 14 2 1.8 16 Levofloxacin 1 5.7 48 Moxifloxacin 0.25 18 192 Gatifloxacin 0.5 8.4 68 Pseudomonas aeruginosa Fluoroquinolone MIC (c) Cmax:MIC AUIC Ciprofloxacin 4 0.75 7 4 0.9 8 Levofloxacin 16 0.36 3 Moxifloxacin 8 0.56 6 Gatifloxacin 8 0.52 4.25 (a) Cmax, peak serum concentration of the drug; AUC, area under the curve; MIC, AUIC, ratio of the AUC to MIC.