AVWSAcquired Von Willebrand Syndrome
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References in periodicals archive ?
AVWS secondary to cardiac causes such as aortic stenosis and ventricular-assist devices [6, 7].
Potential mechanisms for AVWS associated with MGUS include vWF-specific inhibitors [3, 4, 8, 10, 11], adsorption of vWF multimers onto malignant cells [3, 4, 10, 12], formation of immune complexes between vWF and nonspecific antibodies [10,13], and increased degradation of vWF multimers [4, 14].
Management of AVWS focuses on treating the underlying etiology, treatment of bleeding, and prevention of bleeding in high risk situations (i.e., surgery).
The cornerstone of treatment for AVWS is to treat the underlying disorder.