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"By achieving these certifications we have demonstrated that AWCCS is committed to maintaining international standards in quality, health and safety and the environment," said Paul Greenwood, CEO of AWCCS.
Figure 1 shows the ROC curve for the primary study endpoint of one-year mortality for all subjects according to the individual scoring systems analysed: CCS, AWCCS, MEDS and SOFA.
As can be seen, MEDS x AWCCS has the highest AUC but the result is not significantly different from that of AWCCS alone.
In our results, SOFA performed better than MEDS or AWCCS for predicting short-term mortality and ICU admission, but not long-term mortality, where AWCCS performed best.
To determine whether the observed 0.05 difference in AUC between MEDS and AWCCS was statistically significant would require a study sample of 700 subjects, and even then the clinical implications of detecting this difference where both scores are of only moderate discriminatory value is questionable.
We have demonstrated that in a small population of patients who present to ED with severe sepsis or shock with sepsis, AWCCS is a reasonable discriminator of longer-term mortality.
ROC = receiver operating characteristics, CCS = Charlson Comorbidity Score, MEDS = Mortality in Emergency Department Sepsis, SOFA = Sequential Organ Failure Assessment, AWCCS = age-weighted Charlson Comorbidity Score.
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