AXINAxis Inhibitor
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In several studies, elevated levels of nuclear [beta]-catenin in various human cancers have been demonstrated as a hallmark of active WNT/[beta]-catenin signaling, while mutations of AXIN gene were significantly less frequent [21].
Notably, a range of human cancers shows elevated levels of nuclear [beta]-catenin, a hallmark of active WNT/[beta] -catenin signaling while mutations of APC, AXIN or CTNNBi genes are substantially less frequent.
Mutations in other genes of the Wnt pathways, such as axins or APC, have not been observed in sporadic HA.