AXINAxis Inhibitor
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Joo, "Ectopic expression of axin blocks neuronal differentiation of embryonic carcinoma P19 cells," Journal of Biological Chemistry, vol.
Upon binding of Wnt to Fzd, the coreceptor low density lipoprotein 5/6 (LRP5/6) interacts with Fzd and dishevelled (DVL), leading to the recruitment of APC and Axin to the plasma membrane along with CK1a and GSK3[beta].
In the Drosophila germarium, altered Wingless (Wg; the fly Wnt homologue) signaling occurs in ovarian germline stem cells (GSCs) through removal of its regulators such as dishevelled, armadillo, Axin, and shaggy; this causes GSC loss, influences follicle cell proliferation, and induces differentiation [34, 35].
Kim et al., "Axin pathway activity regulates in vivo pY654-[beta]-catenin accumulation and pulmonary fibrosis," Journal of Biological Chemistry, vol.
Liu et al., "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling," Nature, vol.
The main components of the Wnt/[beta]-catenin signaling pathway include the secreted protein Wnt family, the transmembrane receptor Frizzled family, low-density lipoprotein receptor-related protein (LRP), Dishevelled (Dsh), glycogen synthase kinase3[beta] (GSK3[beta]), Axin, [beta]-catenin, adenomatous polyposis coli protein (APC), and the transcription factor T cell factor/lymphoid enhancer factor (TCF/LEF) family.
In the absence of Wnt signals, cytoplasmic betacatenin forms a complex with scaffolding proteins APC and axin and is phosphorylated at specific serine and/or threonine residues by GSK-3beta.
Citing the Axin WAPDA Badin, Deputy Commissioner Badin stressed him to reduce hours of load-shedding immediately as district administration was facing hurdles in providing the water to the citizens adding he stressed over the WAPDA authorities to avoid unnecessary and unannounced power-outage in the city.
In Disrupt IT: A New Model for IT in the Digital Age, Ian Cox notes the importance of engagement and collaboration when dealing with disruptive technologies (Axin Ltd., 2014).
If the Wnt/[beta]-catenin signaling pathway is not activated, cytoplasmic [beta]-catenin levels are maintained low through continuous proteasome-mediated degradation, which is controlled by a multiprotein complex containing glycogen synthase kinase 3[beta] (GSK-3[beta]), adenomatous polyposis coli, and Axin.