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References in periodicals archive ?
The Physicians Health Study was the first to show that chronic aspirin use could prevent a first myocardial infarction.4 Pooled estimates from the first 6 studies of aspirin for primary prevention indicated a 12% relative reduction (0.06% absolute risk reduction) in first CVD events in contrast to the 22% relative reduction seen in secondary prevention.5 Another meta-analysis demonstrated a greater effect in first CVD events in the initial 3 years of these trials.6 This finding may reflect decreasing adherence with aspirin over the longer duration of the primary prevention trials.
The relative risk reductions in cardiovascular death/hospitalization for heart failure were more similar, but the absolute risk reductions tended to be greater: 1.9% and 0.6% in patients with and without previous Ml, respectively.
Instead of reporting the absolute risk reduction, most media reported something called the relative risk, which measures the probability of an event occurring in one group compared with the probability of the event occurring in the comparison group.
RR for all cause ER visit was 0.46 (95% confidence interval [CI] 0.21-1.00) with absolute risk reduction of 21.5% and number needed to treat of 5.
The absolute risk reduction was 23%, and number of patients needed to treat (NNT) was 5.
b) A 14% absolute risk reduction in mortality was observed for participants who consumed spicy foods 6 or 7 days a week compared to those who ate spicy foods less than once a week
As in many other studies of this type, enthusiastic researchers cite the relative risk reduction (53 percent), which looks much more impressive than the absolute risk reduction from about 3.67 percent to about 1.75 percent--a difference of less than two percent.
During a median treatment duration of 4.5 years, first stroke occurred in 282 participants (2.7%) in the enalapril-folic acid group compared with 355 participants (3.4%) in the enalapril group, representing an absolute risk reduction of 0.7% and a relative risk reduction of 21%.
Relative risk and absolute risk reduction was computed and appraised, and the results were explained using random effects models.
The term "absolute risk reduction" was understood by 19(24%) (Table-1).
[6,7] When results from the other two trials are adjusted for the known sources of error bias, the estimated relative reduction in HIV risk in these trials is also considerably less than the reported 60% (and the absolute risk reduction falls commensurately) (personal communication--R S van Howe, 12 March 2011).
an absolute risk reduction of approximately 3 major cardiovascular events [myocardial infarction, stroke, and CV-related death] per 1000 person-years, for a relative risk reduction of approximately 30% among high-risk persons who were initially free of cardiovascular disease," compared with controls.