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ASPIRINAcetyl Salicylic Acid
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Abbreviations MB: Mung bean GMB: Germinated mung bean FMB: Fermented mung bean DMEM: Dulbecco's modified eagle medium LPS: Lipopolysaccharide MTT: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide NO: Nitric oxide ASA: Acetyl salicylic acid IFN-[gamma]: Interferon-gamma GABA: [gamma]-Aminobutyric acid.
Fresh acetyl salicylic acid solution was prepared just before use by dissolving the compound in 0.1 M NaHC[O.sub.3] and immediately neutralizing the solution to pH 7.0 at 0[degrees]C which was discarded after use [19].
Another group of rats was administered with acetyl salicylic acid (5.0, 10, 20 mg/kg body weight, p.o.) in 1.0% CMC as a standard reference drug.
He was discharged on the fifth day on 300 mg of oral acetyl salicylic acid, 75 mg of clopidogrel, 2.5 mg of perindopril daily with instruction of avoiding usage of any illicit drug.
The result was acetyl salicylic acid which was marketed as Aspirin.
These data suggest a molecular mechanism for the anti-inflammatory effect of sesquiterpene lactones, which differs from that of other nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and acetyl salicylic acid.