ActRIIB


Also found in: Medical.
AcronymDefinition
ActRIIBActivin A Receptor, Type IIB
References in periodicals archive ?
Activin and MSTN bind directly to one of two isoforms of type II receptors: ActRIIA and ActRIIB (Donaldson et al.
One approach to inhibiting the MSTN effect is by blocking its signaling, which is initiated by interaction with the ActRIIB receptor.
The collaboration will initially investigate ACE-031, Acceleron's lead ActRIIB drug candidate, currently in a Phase IIa trial for the treatment of patients with Duchenne Muscular Dystrophy (DMD).
Shire will receive an exclusive license to Acceleron's ActRIIB molecules, including ACE-031, in markets outside of North America.
ACE-031 is a completely human, recombinant fusion protein that is produced by joining a portion of the human ActRIIB receptor to a portion of a human antibody.
ACE-031, a soluble fusion protein based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor.
ACE-031, a soluble molecule based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor.
ActRIIB binds to myostatin (GDF-8) and other negative regulators of muscle mass and strength.