ATF4

(redirected from Activating Transcription Factor 4)
Also found in: Medical.
AcronymDefinition
ATF4Activating Transcription Factor 4
References in periodicals archive ?
ATF4, activating transcription factor 4; eIF2[alpha], eukaryotic translation initiation factor 2; IDO1, indoleamine 2,3-dioxygenase 1; IFN, interferon; IFNAR, interferon alpha/beta receptor; IRF, interferon regulatory factor; ISGF3, interferon- stimulated gene factor 3; PD1, programmed death 1; PDL1, programmed death ligand 1; STAT, signal transducer and activator of transcription.
ATF4, activating transcription factor 4; CHOP, C/EBP homolog protein; eIF2[alpha], eukaryotic translation initiation factor 2[alpha]; GADD34, growth arrest and DNA-damage inducible 34; GCN2, general control nonderepressible 2; HRI, haem-regulated inhibitor kinase; P, inorganic phosphate; PERK, protein kinase RNA-like endoplasmic reticulum kinase; PKR, double-stranded RNA-activated protein kinase; PP1, protein phosphatase 1.
In the present study, apoptosis and cell viability in the condition of ERS, activating transcription factor 4 (ATF4) (UPR biomarker) and light chain 3 (LC3) turnover (marker of autophagy) were detected in human oligodendrocyte cell line transfected with missense, deletion or truncated mutations that influence eIF2B?
Hu et al., "Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein.
After exposure to 10 [micro]M Cd[Cl.sub.2], the levels of activating transcription factor 4 (ATF4) were increased at 2 hr, with a further enhancement after that; this accumulation followed the transient but marked phosphorylation of the [alpha] subunit of eukaryotic translation initiation factor 2 (eIF2[alpha]) on serine 51.
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