AGVH

(redirected from Acute Graft Versus Host)
AcronymDefinition
AGVHAcute Graft Versus Host (disease)
References in periodicals archive ?
Proceeds of the Private Placement will be used to fund preparatory work for initiation of the Company's Phase 3 clinical registration study for its lead product development program evaluating cannabidiol ('CBD') for the prevention of acute graft versus host disease ('GVHD').
NEW YORK, N.Y., April 16, 2019 -- Mesoblast Limited (NASDAQ:MESO) announced that the FDA has agreed that Australian stem cell company Mesoblast can submit on a rolling basis a Biologies License Application (BLA) for its allogeneic cellular medicine remestemcel-L in children with steroid-refractory acute Graft versus Host Disease (SR-aGVHD).
NEW YORK, N.Y., April 16, 2019 -- Mesoblast Limited (NASDAQ:MESO) announced that the FDA has agreed that Australian stem cell company Mesoblast can submit on a rolling basis a Biologics License Application (BLA) for its allogeneic cellular medicine remestemcel-L in children with steroid-refractory acute Graft versus Host Disease (SR-aGVHD).
The importance of this concept is shown by the successful Phase 1 clinical trial for the treatment of GvHD by Cynata Therapeutics and the National Health Service (U.K.) ("An Open-Label Phase 1 Study to Investigate the Safety and Efficacy of CYP-001 for the Treatment of Adults With Steroid-Resistant Acute Graft Versus Host Disease").
Mesoblast announced that the FDA has agreed that Mesoblast can submit on a rolling basis a Biologics License Application, or BLA, for its allogeneic cellular medicine remestemcel-L in children with steroid-refractory acute Graft Versus Host Disease, or SR-aGVHD.
Acute graft versus host disease stages Clinical Stage Lower GI Upper GI 1 Diarrhea <500 mL/day Nausea/vomiting 2 Diarrhea 500-1000 mL/day 3 Diarrhea 1000-1500 mL/day 4 Diarrhea >1500 mL/day Clinical Stage Liver (Bilirubin mg/dL) 1 2-3 2 3-6 3 6-15 4 >15 Table 3.
MSCs have been used since 2000 to treat various hematologic and autoimmune diseases, including acute graft versus host disease (aGvHD).
Hildebrandt, "The chemokine system: a possible therapeutic target in acute graft versus host disease," Current Topics in Microbiology and Immunology, vol.
Tian et al., "IL-22 promoted [CD3.sup.+] T cell infiltration by IL-22R induced STAT3 phosphorylation in murine acute graft versus host disease target organs after allogeneic bone marrow transplantation," International Immunopharmacology, vol.
The company plans to conduct the Phase one clinical trial, which is entitled 'An Open-Label Phase 1 Study to Investigate the Safety and Efficacy of CYP-001 for the Treatment of Adults With Steroid-Resistant Acute Graft Versus Host Disease', at a number of clinical centres in the UK and Australia.
"Importantly, in 2014 we plan to have active products in Phase 3 clinical trials in all four core major therapeutic areas of focus: cardiovascular medicine (congestive heart failure) inflammatory/ immune diseases (Crohn's disease), orthopedics (spinal fusion and interverbral disc repair) and oncology (acute Graft versus Host Disease and cord blood expansion in bone marrow transplantation."
Full browser ?