Pertussis or whooping cough, generally considered as the disease of infants and children, is an acute respiratory tract disease
responsible for around 300,000 deaths annually.1 However, recent reports from many countries of the world clearly indicate that this disease targets people of all age groups including adolescents and adults.2 Pertussis remains an underestimated and under reported disease in adolescents and adults due to atypical symptoms in these age groups.
The role of BK virus in acute respiratory tract disease
and the presence of BKV DNA in tonsils.
In France, from November 2006 through June 2007, nasopharyngeal aspirates were obtained from 537 children who were <5 years of age and who had acute respiratory tract disease
. The aspirates were tested for respiratory syncytial virus (RSV); influenza virus types A and B; parainfluenza virus types 1, 2, and 3; and adenoviruses (AdVs) by direct immunofluorescence assay.
positive (%) p value Control 81 28 (34.5) Hepatitis 81 29 (35.8) 1 HBV 20 10 (50) 0.30 HCV 11 5 (45.4) 0.71 Others 19 7 (36.8) 0.93 Unknown 31 7 (22.5) 0.3 ARD 40 27 (67.5) 0.001 ([dagger]) Vasculitis 30 10 (33.3) 0.91 KID 12 6 (50) 0.47 HSP 18 4 (22.2) 0.46 Total 232 94 (40.5) * SAV, small anellovirus; HBV, hepatitis B virus; HCV, hepatitis C virus; ARID, acute respiratory tract disease
; KID, Kawasaki disease; HSP, Henoch-Schonlein purpura.
The study sample comprised 589 children <5 years of age who were admitted to a pediatric unit of the University Hospital of Montpellier (France) for acute respiratory tract disease
, from November 2003 to October 2004.
Although HMPV and SARS-CoV might differ in transmission efficiency, their role and clinical outcome in acute respiratory tract disease
need to be distinguished.