Qiu et al., "Allogeneic bone marrow-derived mesenchymal stromal cells for hepatitis B virus-related
acute-on-chronic liver failure: a randomized controlled trial," Hepatology, vol.
In our country, hepatitis B virus (HBV) infection is the main cause of
acute-on-chronic liver failure (ACLF) [3], the mortality of which is as high as 62.18%-72.3% [4-6].
In the latter clinical constellation, this syndrome has been referred to as
acute-on-chronic liver failure (ACLF) [1, 2].
Clinically,
acute-on-chronic liver failure (ACLF) is a potentially lethal disease with a higher mortality than acute liver failure (ALF), characterized by the rapid deterioration of liver function [3, 22].
Impact of Acute Insults on the Natural History of Cirrhosis ("
Acute-on-Chronic Liver Failure") Viral Hepatitis.In: Garcia-Tsao G, Kamath P, editores.
Acute liver failure (ALF), fulminant hepatic failure (FHF) and
acute-on-chronic liver failure (ACLF) are a growing reason for admission to pediatric and adult intensive care units.
Improvement of impaired albumin binding capacity in
acute-on-chronic liver failure by albumin dialysis.
"What we've begun to see and to believe more and more is that these patients begin to deteriorate when they develop
acute-on-chronic liver failure because of the steady buildup .of toxins in the circulation, which leads to further damage to the liver.
We concentrated on a cohort of patients with hepatitis B-related
acute-on-chronic liver failure (HBACLF).
Our previous systematic review and meta-analysis suggested that the performance of MELD score had a higher specificity than the Child-Pugh score for the assessment of prognosis in patients with
acute-on-chronic liver failure (3).
These range from orphan indications, such as rare inborn metabolic diseases including urea cycle disorders (UCD) to large indications such as
acute-on-chronic liver failure (ACLF), and nonalcoholic steatohepatits (NASH)/fibrosis.
Currently, emricasan is in a Phase 2b clinical trial in patients with
acute-on-chronic liver failure, as well as a Phase 2 clinical trial in patients with severe alcoholic hepatitis, concluded the company.
