Ad7Adenovirus Type 7
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To assess whether Ad7 was associated with severe disease, diagnoses of inpatients were dichotomised as invasive (pneumonia, gastroenteritis, disseminated disease, or hemorrhagic cystitis) and noninvasive (upper respiratory tract infection, acute laryngotracheobronchitis, bronchitis, bronchiolitis, tonsillitis, otitis media, or conjunctivitis) on the basis of clinical syndromes identified by physicians.
This increase was predominantly related to Ad7 infections, which were first detected in November 2012 and represented 48.
To date, PaxVax has bioengineered dozens of vaccine candidates using the Ad4 and Ad7 vector technology.
A nationwide outbreak of severe pneumonia caused by Ad7 occurred in Korea from 1995 to 2000 (7).
Different Ad7 genome types have predominated in different areas during the last 3 decades (5-8,10,11).
We present a retrospective study of Ad7 isolates in Iowa.
In 2002, data suggest that Ad7d2 supplanted all other Ad7 genome types (9 of 9 Ad7 isolates were A7d2) (Figure).
An additional 27 unrelated Ad7 community isolates collected between 1995 and 2000 were provided by several healthcare centers in the New York City area for comparison with the outbreak strains.
Of the 28 additional Ad7 field isolates from the New York City area that were epidemiologically unrelated to the outbreak, 24 were identified as Ad7b and 4 as Ad7d2; none possessed the unique SmaI restriction pattern of the outbreak strain (data not shown).
Since 1996, Ad7d2 has been responsible for several civilian outbreaks of Ad7 disease and was the primary cause of a large outbreak of respiratory illness at a military recruit training center.
Contract Awarded for AD7S FTE in Support of F-35A Clearance Activities