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Ad5Adenovirus Type 5
Ad5Alzheimer Disease 5 (gene)
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CG0070, a selectively replicative oncolytic immunotherapy based on a modified adenovirus type 5 backbone that contains a cancer-selective promoter and a GM-CSF transgene, destroys bladder tumor cells through their defective Rb pathway.
Human replication deficient adenovirus type 5 expressing the ASP-2 gene (AdASP-2) or TS gene (AdTS) was generated and produced as described earlier [25]Control mice were immunized with pcDNA3 and human replication deficient adenovirus type 5 expressing [beta]-galactosidase (Ad[beta]-gal).
Although the difference in infection rates between the vaccine and placebo groups across the entire study population was only "marginally statistically significant," in the subgroup of participants with high levels of adenovirus type 5 (Ad5) immunity--defined as antibody levels greater than 200 U--the statistical significance between the two groups was more robust.
Recombinant AAAV virions were generated by simultaneous transfection of HEK 293 cell monolayers, with three plasmid constructs: the p3.6 ITR-MCS containing the VP2, the pRC-CMV expressing the Rep and Cap coding regions of AAAV [8] and a commercial pHelper plasmid coding for the E2, E4 and VR-RNA genes derived from the human adenovirus type 5 (Stratagene, La Jolla, CA.
The agreement comes after researchers found that monkeys injected with Merck's replication-defective adenovirus type 5 vector (Ad5) vaccine and then later with Aventis' canary pox virus vector (ALVAC) vaccine developed immune systems that were better prepared to combat AIDS than monkeys given either vaccine separately or in the reverse order.
Based on Vaxart's proprietary oral vaccine delivery platform, the Ebola vaccine candidate is a disabled virus (non-replicating adenovirus type 5, or Ad5) that co-delivers the gene for the specific vaccine antigen and the gene for a TLR3 ligand that functions as an adjuvant to amplify the immune response.
The vaccine consisted of live recombinant human adenovirus type 5 vector, expressing rabies virus glycoprotein (AdRG1.3) (Onrab).
AdRG1.3 is an alternative to V-RG that might have a different human safety profile given the high prevalence of antibodies in humans to human adenovirus type 5 and the mild illness that typically results from infection with this virus (7).
The complete nucleic acid sequence of the adenovirus type 5 reference material (ARM) genome.
The functions of E4 ORF 6/7 peptides of Ad7 are unknown, but the corresponding protein of adenovirus type 5 has the ability to induce the binding of cellular transcription factor E2F to the viral E2a promoter region (26).
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