Haemmerle, "Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
," Science, vol.
Abbreviations: PPAR[alpha], peroxisome proliferator-activated receptor alpha; PGC-1[alpha], peroxisome proliferator-activated receptor gamma coactivator-1 alpha; CPT1, carnitine palmitoyltransferase 1; AMPK, AMP-activated protein kinase; AICAR, 5-aminoimidazole-4-carboxamide-1-[beta]-D-riboside; cpdC, compound C; HSL, hormonesensitive lipase; ATGL, adipose triglyceride lipase
; ACC, acetyl-CoA carboxylase; FAO, fatty acid oxidation; CRE, cAMP response element; CREB, CRE-binding protein; SIRT1, silent information regulator T1; HDAC, histone deacetylase; ERK1/2, extracellular signal-regulated protein kinases 1 and 2; EMSA.
Myocardial infarction significantly reduced adipose tissue mass, and this loss can be promoted, at least in part, by reduced perilipin protein expression, favoring action of lipases, particularly hormone-sensitive lipase and adipose triglyceride lipase. ATGL and HSL are able to degrade TG by cleaving the ester bond, thus governing the lipolysis pathway in adipose tissue .
Ribet et al., "Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes," The Journal of Biological Chemistry, vol.
Lass, "Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores," Journal of Lipid Research, vol.
Ciriolo, "Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARalpha-PGC-1alpha antioxidant response," Oncotarget, vol.
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
. Science 2006; 312: 734-737, doi: 10.1126/science.
In this study, DR did not affect the expression of several genes in the LM for lipid metabolism (adipose triglyceride lipase
, acyl-CoA synthetase long-chain family member, glycerol-3-phosphate acyltransferase, and hydroxyacyl-Coenzyme A dehydrogenase) and fatty acid uptake (fatty acid translocase and lipoprotein lipase) at both P1 and P2.
A similar paradox is presented in subjects with loss of function mutations in the adipose triglyceride lipase
(ATGL) gene .
Lossner et al., "Isoproterenol, TNF[alpha], and insulin downregulate adipose triglyceride lipase
in 3T3-L1 adipocytes," Molecular and Cellular Endocrinology, vol.
In addition, besides perilipin and HSL, lipolysis stimulated by catecholamines is related to other molecules including AMP-activated protein kinase (AMPK), adipose triglyceride lipase
Adipose triglyceride lipase
(ATGL) and hormone-sensitive lipase (HSL) both have the capacity to degrade TG by cleaving the ester bond, thus governing the lipolysis pathway in adipose tissue .