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AEoCAdvanced Epithelial Ovarian Cancer
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Wang, "Complete cytoreductive surgery is feasible and maximizes survival in patients with advanced epithelial ovarian cancer: a prospective study," Gynecologic Oncology, vol.
ORLANDO -- Only a minority of women in the Medicare population with advanced epithelial ovarian cancer receive optimal therapy with a combination of surgery and six cycles of chemotherapy, according to a large, retrospective study.
Serum CA 125 is significantly elevated in over 90% of patients with advanced epithelial ovarian cancer and 40% of overall cases with advanced intra-abdominal malignancies.5 A recent published study has shown that elevated serum CA125 ( greater than 351U/ml) could be found in many benign condition such as menstruation, pregnancy6, functional cyst, pelvic infection, and endometriosis7'8.
Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials; by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO).
Serum CA 125 levels are used to assess response to therapy and to detect recurrences, mainly in advanced epithelial ovarian cancer. Some studies have looked at CA 125 levels before chemotherapy in stage I disease.
Most women with advanced epithelial ovarian cancer receive initial surgery followed by intensive platinum/taxane combination chemotherapy.
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