AOC

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AcronymDefinition
AOCAustralian Olympic Committee
AOCAdministrative Office of the Courts
AOCAge Of Conan (game)
AOCArchdiocese of Chicago (Chicago, IL)
AOCActive Optical Cable (various organizations)
AOCAdvent of Code (programming)
AOCArea of Concern
AOCArchitect of the Capitol
AOCAll Our Children (various organizations)
AOCAir Operator Certificate
AOCApplied Organometallic Chemistry (John Wiley & Sons, Ltd.)
AOCAdvice of Charge (Sprint)
AOCAlliance of Civilizations (UN)
AOCAssociation of Old Crows
AOCAge of Champions (gaming)
AOCAssociation of Colleges (UK)
AOCAmbassadors of Christ
AOCAdministrative Order on Consent
AOCArt of Charm (Charismatic, Confident, Social Interaction)
AOCArt of Charm
AOCArea Of Concentration
AOCAir Operations Center
AOCAuxiliary Output Chip
AOCAdvice of Charge
AOCAccess Overload Class
AOCAdsl Overhead Control Channel
AOCAbundance of Caution (financial lending classification)
AOCAir and Space Operations Center (previously: Air Operations Center)
AOCAsian Organized Crime
AOCArmy Operating Concept (US Army)
AOCAnnual Operating Cost
AOCAppelation d'Origine Contrôlée (French wines)
AOCAir Officer Commanding (RAAF)
AOCAMCOM (Aviation and Missile Command) Operations Center
AOCAssociation of Oregon Counties
AOCAutonomy Oriented Computing
AOCAircraft Operations Center
AOCAIDS Outreach Center (Fort Worth, TX)
AOCAssimilable Organic Carbon
AOCArea of Contamination
AOCAreas of Concentration
AOCAdvanced Ovarian Cancer
AOCAdvanced Operations Course (various organizations)
AOCApproximate Original Contour (topography)
AOCAlliance of Churches (Alliance, OH)
AOCArmy Ordnance Corps (various armed forces)
AOCArticles of Confederation (US pre-Constitution government document)
AOCAlabama Organ Center (est. 1968)
AOCApple on Campus (Apple Inc.)
AOCAnnals of Communism (documentary series)
AOCAttestation of Conformity
AOCAmerican Orthodox Church
AOCAward Of Contract
AOCAir Operating Certificate
AOCArmy Operations Center
AOCAirline Operations Center
AOCAgent of Change
AOCAeronautical Operational Control
AOCAmbler Olympic Club (Ambler, PA)
AOCAirline Operational Control (FAA)
AOCArk of the Covenant (Bible)
AOCAdministrator on Call
AOCAerospace Operations Center
AOCAdministrative Order of Consent
AOCArabian Oil Co. (Japan)
AOCArea of Consideration (employment)
AOCAny Other Color (animal breeding/shows)
AOCArt of Conquest (Empire Earth game expansion)
AOCAviation Officer Candidate
AOCApostolic Orthodox Church
AOCAntiochian Orthodox Church
AOCAfrican Orthodox Church
AOCAirport Operations Center
AOCAge of Conquerors (game expansion)
AOCAlberta Online Consortium (Alberta, Canada)
AOCArchitectural Openings Consultant (professional certification)
AOCAlabama Open Carry (also seen as ALOC; pro-gun Internet community)
AOCAirline Operational Communication (data link)
AOCAir Officer Commander
AOCOxygen Arc Cutting
AOCAmerican Optical Company
AOCChief Aviation Ordnanceman (Naval rating)
AOCAirline Operation Center (air traffic)
AOCAbnormal Operating Condition(s)
AOCAngels on Call (Tribulation Force Headquarters)
AOCArmy Operations Course (Canadian)
AOCArts Orange County (California)
AOCAnglican Orthodox Church (Statesville, NC)
AOCAutomatic Overload Control
AOCAutomatic Output Control (cellular phone transmitter control)
AOCActive Object Class
AOCAutomated Operations Control
AOCADSL Overhead Channel
AOCAviation Ordnance Chief
AOCAlbanian Orthodox Church
AOCAdvice of Correction
AOCAmerican Oilseed Coalition
AOCAirlines Operators' Committee
AOCAirlift Operations Center
AOCAdvice of Change
AOCAccounting Operations Center (US NPS)
AOCArgument Order Change
AOCAnglaises Ont la Côte (French automobile association)
AOCAirlines Operations Center
AOCAnalytical Operations/Data Quality Center (EPA)
AOCAirline Operating Center
AOCActive Optics Compensation
AOCAdvanced Operating Capability
AOCAerojet Ordnance Company
AOCAdministrative Operations Committee
AOCArtists’ Owned Collective (Tacoma, WA gallery)
AOCAudio Operator Console (Crystal)
AOCAction Office Contact
AOCAmeritech Operating Company
AOCAction Officer Code
AOCAssistant Operations Controller
AOCAgricultural Outlook Conference
AOCAutomatic Opening Capability (parachute feature)
AOCAutomobiles d'Origine et de Collection (French automobile club)
AOCAUTODIN Operators Console
AOCAllied Operational Center
AOCAlmost-Optimal Coset
AOCAwaiting Outgoing Continuity
AOCAshland Oil Company
AOCAdministrative Overhead Center
AOCAdditional Operational Capability
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References in periodicals archive ?
- UK-based pharmaceutical comapny AstraZeneca and US-based Merck and Co., Inc (NYSE: MRK) have received positive results from the Phase III PAOLA-1 trial in women with advanced ovarian cancer, the companies said.
Jose Baselga, executive vice president, Oncology R&D, AstraZeneca, said, 'The positive results from the PAOLA-1 trial demonstrate a clear potential benefit of adding LYNPARZA to the standard treatment bevacizumab for women with advanced ovarian cancer. Following positive results from the SOLO-1 trial for women with a BRCA gene mutation, the PAOLA-1 trial marks yet another positive Phase 3 trial for LYNPARZA as a first-line maintenance treatment for women with advanced ovarian cancer.
Jose Baselga, Executive Vice President, Oncology R&D, said: "The positive results from the PAOLA-1 trial demonstrate a clear potential benefit of adding Lynparza to the standard-treatment bevacizumab for women with advanced ovarian cancer. Following positive results from the SOLO-1 trial for women with a BRCA gene mutation, the PAOLA-1 trial marks yet another positive Phase III trial for Lynparza as a 1st-line maintenance treatment for women with advanced ovarian cancer.
"Following positive results from the SOLO-1 trial for women with a breast cancer gene mutation, the PAOLA-1 trial marks yet another positive Phase III trial for Lynparza as a first-line maintenance treatment for women with advanced ovarian cancer. We look forward to discussing the results with global health authorities as soon as possible."
Olaparib had previously been available to a small number of women who have advanced ovarian cancer and a mutation in the BRCA1 or BRCA2 genes, from after a third round of chemotherapy treatment.
This approval by the Japanese Ministry of Health, Labour and Welfare was based on data from the pivotal phase III SOLO-1 trial, which tested Lynparza as maintenance monotherapy, as compared with placebo, in patients with BRCAm advanced ovarian cancer following first-line platinum-based chemotherapy.
Jose Baselga, Executive Vice President, Oncology R&D, said: "Lynparza provides a much-needed alternative and improvement over standard-of-care chemotherapy for patients with BRCA-mutated, advanced ovarian cancer. This is the fourth positive Phase II/III trial in advanced ovarian cancer for Lynparza, across multiple lines of therapy.
PARP inhibitors also have been approved for treatment of advanced ovarian cancer in BRCA mutation carriers who have received 3 or more lines of platinum-based chemotherapy.
Rafii Tabrizi explained that in 2004 he became involved with the concept of HIPEC - hyperthermic intraperitoneal chemotherapy -- in advanced ovarian cancer. This involves heating the chemotherapy drugs and then applying them directly to the abdominal cavity rather than giving them intravenously.
AstraZeneca Plc (NYSE:AZ), a global, science-led biopharmaceutical company, and pharmaceutical company Merck & Co Inc (Merck)(MSD outside the US and Canada)(NYSE:MRK) announced on Monday that the US Food and Drug Administration (FDA) has accepted a supplemental New Drug Application (sNDA) for Priority Review for the use of Lynparza (olaparib) tablets as a maintenance treatment in patients with newly-diagnosed, BRCA-mutated (BRCAm) advanced ovarian cancer, who were in complete or partial response following 1st-line standard platinum-based chemotherapy.
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