AgNORsArgyrophilic Nucleolar Organizer Region Associated Proteins
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How should we count AgNORS? Proposals for a standardized approach.
AgNOR is helpful in discriminating benign from malignant disease or indistinguishing between low and high grade malignancy.5 AgNORs can prove to be useful, especially in situations in which tissue is insufficient for flowcytometry such as small biopsies and limited needle aspirates.7Study of the proliferation markers help in the proper diagnosis of different breast lesions which lie in the gray zone on routine histopathology.
Some nuclear proteins are associated with NORs and are stained black with silver methods (AgNOR proteins or AgNORs) [22].
Comparison of silver-staining nucleolar organizer region (AgNOR) counts and proliferating cell nuclear antigen (PCNA) expression in reactive mesothelial hyperplasia and malignant mesothelioma.
To infer cytotaxonomic relationships within Ostreinae, we constructed ideograms, based on relative length and centromeric index values, number and location of major ribosomal genes (either by FISH with ITS1 or AgNORs), and C-banding (Fig.
Molecular factors associated with prognosis are hormone receptor status, HER 2 status, Ki-67 and Argyrophilic Nucleolar Organizer Regions (AgNORs) silver stains.5,6
[46] Nucleolar organizer regions (NORs) are loops of ribosomal DNA found in the nucleolus that can transcribe for ribosomal RNA associated with non-histone nucleoproteins which can be identified by silver staining (AgNORs) which denotes the proliferative activity and prognosis of lesions.
Also, most studies discuss only the diploid number and location of the AgNORs, ignoring important markers as heterochromatin distribution and mapping of rDNAs sites.
labrosus population of the Capivara Reservoir reviewed by Carvalho and Dias (2007), hybridisation with the 18S rDNA probe also showed signals corresponding to AgNORs in a pair of st-chromosomes and on the long arm in the terminal position, as in the population from the Tibagi River.
Quantitative estimation of AgNORs in oral normal, dysplastic and carcinomatous lesions.