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ALDOSAldosterone Synthase
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has signed an exclusive license with ElexoPharm GmbH of Saarbrucken, Germany for compounds that target aldosterone synthase (CYP11B2), a cytochrome P450 enzyme involved in the generation of aldosterone, the company said.
Access to Aldosterone Synthase Inhibitors and Chiral Precatalysts Shufen Xu, RSc., Brock University, WO 2007/024945 AI.
Previous studies demonstrated that the polymorphic variation of CYP11B2, the gene encoding aldosterone synthase, was associated with increased aldosterone metabolite excretion and hypertension [23-27].
In infancy, aldosterone synthase deficiency generally takes the form of a life-threatening electrolyte imbalance.
Aldosterone synthase inhibitors have become a new option for the treatment of hypertension, heart failure, and renal disorders, as they are able to decrease aldosterone concentrations in plasma and target organs (5).
The purification of the aldosterone synthase, CYP11B2, was accomplished by Ogishima, Mitani and Ishimura in 1989 from zG of the adrenal cortex of sodium-deficient and potassium-repleted rats.
Abbreviations ACE: Angiotensin-converting enzyme AGT: Angiotensinogen AGTR1: Angiotensin II type I receptor CYP11B2: Aldosterone synthase eGFR: Estimated glomerular filtration rate ESRD: End-stage renal stage LRM: Logistic regression model MDR: Multifactor dimensionality reduction PCR: Polymerase chain reaction RAAS: Renin-angiotensin-aldosterone system RFLP: Restriction fragment length polymorphism SD: Standard deviation SNPs: Single nucleotide polymorphisms.
Amongst RAAS genes studied till date, CYP11B2 gene (CYP11B2) encoding aldosterone synthase has emerged as a strong candidate gene for hypertension.
The relative mRNA levels of the 11[beta]-hydroxylase (CYP11B1), aldosterone synthase (CYP11B2), and 17ahydroxylase (CYP17A1) genes were standardized to GAPDH using the [2.sup.-[DELTA][DELTA]CT] method.
CYP11B1 (11b-hydroxylaze) and CYP11B2 (aldosterone synthase), which share more than 90% of their amino acid sequences, encode the enzymes responsible for the three terminal steps in aldosterone formation [2].