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T-RAAll-Trans-Retinoic Acid
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Astier et al., "All-trans-retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting NF-[kappa]B signaling," The Journal of Nutritional Biochemistry, vol.
Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes.
In eight chapters, international researchers present recent developments including the introduction of all-trans-retinoic acid (ATRA), a molecular-targeted drug that has revolutionized treatment of a type of leukemia; vitamin A metabolism; current understanding of the role of retinoids in key physiological functions; the role of carotenoids and retinoic acids in prevention/ treatment of diseases including asthma, lung cancer, and macular degeneration; and the evaluation of such compounds by DNA microarray technology.
Outcome of childhood acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy.
Another in vitro study found that kinetin, EGCG (a component found in green tea), all-trans-retinoic acid and selenium induced changes in the aging-related proteins moesin, rho guanosine-5'-diphosphate-dissociation inhibitor, and actin, providing a possible mechanism for their role in preventing skin aging (16).
Three isotypes of retinoic acid receptors (RARs: RAR[alpha], RAR[beta] and RAR[gamma]) are receptors for retinoids such as all-trans-retinoic acid (ATRA) (Petkovich et al., 1987; Brand et al., 1988; Krust et al., 1989).
Although a combination of all-trans-retinoic acid (ATRA) differentiation therapy and chemotherapy successfully induces remission in the majority of patients harboring the PML/RAR[alpha] transcript, approximately one-third of these patients relapse (3).
Stock solutions of 2 x [10.sup.-2] M were made in dimethyl sulfoxide (DMSO) from all-trans-retinoic acid (Sigma Chemical Co.) and stored at -20 [degrees] C.
All-trans-retinoic acid (ATRA), and 1,25 dihydroxyvitamin [D.sub.3] (1,25 [D.sub.3]) are the most well recognized examples of these two classes of hormone-acting nutrients.
of the Memorial Sloan-Kettering Cancer Center in New York City reports administering tretinoin (all-trans-retinoic acid) to 11 patients with APL.
Aggarwal, "Inhibition of all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages," Journal of Leukocyte Biology, vol.
Neuro-2a (N2a), a mouse neuroblastoma cell line, can be induced to differentiate into a neuron-like phenotype by all-trans-retinoic acid, which has been extensively used to study neuronal differentiation, neurite growth, and signaling pathways.
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