United States-based Pfizer and United States-based Merck announced yesterday that avelumab alone or in combination with pegylated liposomal doxorubicin (PLD) has failed to improve overall survival or progression-free survival rate in their phase III Javelin Ovarian 200 trial.
Javelin Ovarian 200 is a multicentre and randomised trial designed to assess the efficacy and safety of avelumab alone or in combination with PLD against PLD alone in 566 women with ovarian cancer that is resistant or refractory to platinum chemotherapy.
The patients in Phase 2 received JTX-2011 0.3 mg/kg every 3 weeks alone or in combination
with nivolumab 240 mg every 3 weeks.
Plasma AT and GT levels increased following supplementation with AT alone or GT alone or in combination
. AT supplementation significantly decreased GT levels.
The Food and Drug Administration approved Trilipix (fenofibric acid) delayed-release capsules for use alone or in combination
with a statin to help improve lipid levels.
Pending approval, the combination will be indicated for the treatment of hypertension and may be used either alone or in combination
with other antihypertensive agents.
None of the seawater samples caused a significant increase in the activity of ER-[beta] receptors, either alone or in combination
Both are now widely marketed, alone or in combination
, to arthritis sufferers for relief of their pain.
Approved March 14, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection in adults.
Approved March 1, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection.
"We will share these results with global health authorities with the goal of bringing this potential treatment option to people with this disease." Currently, Genentech has eight Phase III lung cancer studies underway evaluating TECENTRIQ alone or in combination
with other medicines.