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AEIICAlveolar Epithelial Type II Cells
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Consistent with the known effects of alcohol on liver glutathione levels, the researchers first determined that chronic alcohol ingestion in rats dramatically decreases glutathione levels in the alveolar epithelial lining fluid and in the alveolar epithelial type II cells. (6) In an isolated rat lung, prior chronic alcohol ingestion renders the lung intrinsically susceptible to injury during acute inflammation resulting from exposure to bacteria (Holguin et al.
(6) Alveolar epithelial type II cells synthesize, secrete, and recycle all components of the substance (i.e., surfactant) that serves to maintain the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung.
We found that PA could invade alveolar epithelial type II cells, and it was mediated by lipid raft activation.
Previous studies have indicated a role for interaction between alveolar epithelial type II cells and AMs in the production of iNOS (Pechkovsky et al.