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APUDAmine Precursor Uptake and Decarboxylation (Harrison's Principles of Internal Medicine)
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It has been postulated that outside lung, the tumour arises from the neuroendocrine APUD (amine precursor uptake and decarboxylation) cells, which are widely distributed in the body.3 Histologically, it is undistinguishable from the pulmonary tumour.
Because of these characteristics, Pearse (1) postulated the amine precursor uptake and decarboxylation (APUD) concept, according to which neuroendocrine tumors originate from a single neuroendocrine precursor cell.
The term "karzinoidetumoren" was used in1907 to distinguish carcinoids from carcinomas, and a study demonstrated the amine precursor uptake and decarboxylation properties of EC cells in 1928.5