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AMPHAcute Massive Pulmonary Hemorrhage (microbiology)
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Kameshita, "Identification of amphiphysin 1 as an endogenous substrate for CDKL5, a protein kinase associated with X-linked neurodevelopmental disorder," Archives of Biochemistry and Biophysics, vol.
None of the patients had evidence of other tested paraneoplastic antibodies, including Hu, Yo, CV2, Ri, Ma2, and amphiphysin. Patients were not screened for the presence of unclassified antibodies.
This understanding is also supported by the recent observation that SPS-associated autoantibodies (directed to amphiphysin) are taken up by hippocampal neurons [53].
These data do not exclude the involvement of autoantibodies directed to other autoantigens, such as amphiphysin, in the pathogenesis of SPS [53].
Laporte, "Amphiphysin 2 (BIN1) in physiology and diseases," Journal of Molecular Medicine, vol.
The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of stiff-man syndrome with breast cancer.
These antibodies are directed against two categories of antigens: (1) intracellular antigens (Hu, Ma2, CRMP5, amphiphysin, etc.) and (2) cell surface antigens (the VGKC complex, NMDAR, AMPARs, GABABRs, mGluR5 receptor, GlyRs, etc.).
There are studies on the effects of the serum or CSF IgG antibodies on the neuronal function in cultured cells [22, 23, 38] or on brain slices, but the transfer of clinical or electrophysiological evidence of disease to experimental animals by either systemic or intrathecal injection has not yet been reported, with the exception of mGluR1-Ab in paraneoplastic cerebellar degeneration [39] and reports of GAD-65 or amphiphysin antibodies [40, 41].
# (4) Symptoms cause significant distress or impairment in social, (5) Positive serology: GAD or occupational, or other areas of amphiphysin autoantibodies.