Year of approval Name of the antifungal agent 1958 Amphotericin B deoxycholate 1973 5-Flucytosine 1981 Ketoconazole 1990 Fluconazole 1992 Itraconazole (oral suspension in 1997; intravenous form in 1999) 1995 Amphotericin B lipid complex
1996 Amphotericin B colloidal dispersion 1997 Liposomal amphotericin B 2001 Caspofungin 2002 Voriconazole 2005 Micafungin 2006 Anidulafungin Posaconazole (delayed release of tablet in 2013; 2006 intravenous form in 2014) 9m R 2015 Isavuconazole (Isavuconazonium) (oral and intravenous) Table 2: Spectrum of activity of antifungals against fungi causing invasive disease in critical care [13, 14].
Of note, he had been switched from amphotericin B lipid complex
to voriconazole approximately 3 days prior to his death because the maximum amphotericin B dosage had been reached.
She received several courses of antibiotics for extended periods including imipenem, amikacin, piperacillin/tazobactam, vancomycin, amphotericin B lipid complex
, fluconazole, ciprofloxacin, and tobramycin.
The safest lipid formulations in clinical use are amphotericin B lipid complex
and liposomal formulation; the latter has lower toxicity and greater tolerability compared to the former formulation.
Therapy with amphotericin B lipid complex
. Arch Intern Med 1996;156:337-9.