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References in periodicals archive ?
Hence, the induction of anti-apoptotic proteins expression impressed by hypoxia and MSCs can be involved in the leukemic cells' drug resistance phenomenon and subsequently in the treatment failure.
An anti-apoptotic protein human survivin is a direct inhibitor of caspases 3 and 7.
In fact, TCTPs are calciumbinding (Kim et at, 2000), heat-stable (Mak et aL 2001), and anti-apoptotic proteins (Rho et al., 2011).
However the percentage of cells positive for MUM1, which is major marker of non-GCB immunophenotypic differentiation profile, showed a significantly positive correlation with the positivity percentage of anti-apoptotic protein bcl-xl, pro-apoptotic protein bid, AI, and PI Bai et al.
In this issue Dinand et al (1) report the relationship of EBV and pro- and anti-apoptotic proteins, with clinical and histological factors, and patients' survival in a cohort of Indian childhood Hodgkin lymphoma (HL).
Bax is an important pro-apoptotic protein and Bcl-2 is an important anti-apoptotic protein. It has been reported that multiple signal transduction pathways, including JNK, are capable of modifying Bcl-2 family members to reset susceptibility to apoptosis (Kharbanda et al.
6C-D) by inhibiting the expression of pro-apoptotic proteins Bax and cleaved caspase-3 and increasing the expression of the anti-apoptotic protein Bcl-2.
* Aripiprazole inhibits glutamate-induced neurotoxicity and, in contrast to haloperidol, increases BDNF, glycogen synthase kinase (GSK)-1[beta], and the anti-apoptotic protein Bc1-2.
Further, galectin-in h ibitors exerted thei r effect at molecular levels as evidenced by modulation of tumour suppressor gene product (p53), transcription factors (NFkB) that is necessary for proliferation, Caspases (responsible for induction of apoptosis), matrix metalloproteinases (responsible for cell invasion) and Bcl-2 (an anti-apoptotic protein) in both in vitro and in vivo models.
In conclusion, EBV detection in Indian children with CHL was significantly associated with lower expression levels of the anti-apoptotic protein bak.
Cytosolic A[beta]42 may react with the H3 binding domain of bcl-2 (an anti-apoptotic protein in the mitochondrial membrane).
Zinc stimulates DNA synthesis during its anti-apoptotic action independently with increments of an anti-apoptotic protein Bcl-2 in porcine kidney LLC-P[K.sub.1] cells.