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Anti-CCPAntibodies against Cyclic Citrullinated Proteins
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Disease Durations, DAS 28 Scores, Anti-CCP, and RF Levels Group (n=40) Mean[+ or -]SD DAS28 3.52 [+ or -] 1.60 Disease duration, months 117.60 [+ or -] 65.79 n (%) Anti-CCP Negative 4 (10) Low-positive 5 (12.5) High-positive 31 (77.5) RF Negative 10 (25) Low-positive 15 (37.5) High-positive 15 (37.5) Group (n=40) p Mean[+ or -]SD DAS28 3.23[+ or -]0.996 0.348 Disease duration, months 146.1[+ or -]92.02 0.115 n (%) Anti-CCP Negative 6 (15) Low-positive 9 (22.5) 0.335 High-positive 25 (62.5) RF Negative 14 (35) Low-positive 10 (25) 0.428 High-positive 16 (40) DAS28: disease activity scores; Anti-CCP: anti-cyclic citrullinated peptide; RF: rheumatoid factor.
Recently, the ADVIA Centaur anti-CCP assay (Siemens Healthineers, Erlangen, Germany), which is based on a chemiluminescence immunoassay, has been developed and introduced to clinical laboratories.
Alone, RF or anti-CCP tests are not sufficient for the diagnosis of RA, because some patients have only one or the other biomarker, or lack both.
Table 4 contains detailed information (anti-ARS antibody status, age, sex, MTX and bDMARDs treatments, anti-CCP, and RF values) for patients who tested positive for anti-ARS antibody and had also ILD.
Anti-CCP autoantibodies elicited the largest decrease in QUS index; however, these immune markers were not significantly associated with QUS index (r = -0.43; 95% CI: -1.51-0.65; p = 0.437).
Seror and his colleagues demonstrated that elevated levels of Dkk-1 were associated with radiographic progression even after adjustment of known predictive factors of joint damage (erosions at baseline and anti-CCP positivity) [42].
Laboratory tests revealed a normal blood count, an erythrocyte sedimentation rate of 56 mm/h, C-reactive protein of 2.36 mg/dL, rheumatoid factor of 84.1 IU/mL, and anti-CCP level of 63.2 U/mL.
Our case was also unique in that the positive anti-CCP antibody titre at both the time of diagnosis and during the follow-up suggests the possibility of rheumatoid arthritis (RA).
The rheumatoid factor was 4 (normal 0 to 8), and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) 135.9 (normal 0 to 20).
Objective: To study the erythrocyte sedimentation rate (ESR) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in rheumatoid arthritis patients on disease modifying anti-rheumatic drug therapy.