Primary anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis (AAV) is a chronic multisystem autoimmune disease that includes microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA; Wegener granulomatosis), eosinophilic granulomatosis with polyangiitis (EPGA; Churg-Strauss syndrome), and localized forms of these diseases.
The most common reason of pauci-immune GNs is anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis, including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis, and renal limited vasculitis (1).
The diagnostic value of anti-neutrophil cytoplasmic antibody
testing in a routine clinical setting.
For diagnosing should be used clinical patient data, imaging tests such as chest radiography, MRI or CT scan, biopsy of the lesion and also the presence of anti-neutrophil cytoplasmic antibody
(ANCA)--serum marker of Wegener's granulomatosis--demonstrated by indirect immunofluorescence or ELISA (Enzyme-Linked Immunosorbent Assay).
C3, C4, rheumatoid factor, anti- dsDNA, anti-smith, Anti-neutrophil cytoplasmic antibody
, antitopoisomerase, anti-centromere, anti-Ro, anti-La, anti- RNP, anti-Jo1 and cryoglobulins all were negative.
Serum antinuclear antibodies, anti-dsDNA, anti-neutrophil cytoplasmic antibody
, and ENA panel tests were negative.
Anti-glomerular basement membrane disease (anti-GBM disease) and anti-neutrophil cytoplasmic antibody
(ANCA) vasculitis can coexist.
Antinuclear antibodies (ANA), anti-neutrophil cytoplasmic antibody
(ANCA) and lupus anticoagulant (LA) were negative.
Anti-neutrophil cytoplasmic antibody
(ANCA)- associated vasculitis (AAV) is a group of autoimmune disease that primarily involves the small blood vessels such as the capillaries vessels micro-arteries and venules and AVV commonly affects multiple organs in particular the lungs and
18 October 2011 - US ChemoCentryx Inc said yesterday it had started a phase II study of CCX168, an orally administered small molecule for the treatment of anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis (AAV).
Investigators have made a major advance in treating people with a severe form of vasculitis, anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis, a rare but devastating disease of blood vessels.