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References in periodicals archive ?
The only factor that made a statistically significant difference in a multivariate model was the failure or success of the first antiepilepsy drug regimen that was titrated to the maximum tolerated dose.
In group 1, class A drugs include the antiepilepsy drugs divalproex sodium and topiramate.
These include genetic factors; hypogonadal states; certain endocrine, gastrointestinal, and hematologic disorders; rheumatic and autoimmune diseases; neurologic and musculoskeletal risk factors; and medications such as glucocorticoids, some antiepilepsy drugs, and certain cancer treatments.
The registry, established in 1999, has enrolled 810 women--77% of all Australian women who had taken antiepilepsy drugs (AEDs) for any reason.
Researchers said: ``It has been recognised that treatment with antiepilepsy drugs during pregnancy is associated with an increased risk of major congenital malformation.
Women treated with antiepilepsy drugs needed to be counselled and given better information before a pregnancy so that they were aware of the potential effects of these drugs on the unborn child, they concluded.
Furthermore, antiepilepsy drugs (AEDs) are commonly used to treat other conditions that affect an even greater number of women, such as migraine headaches, other pain conditions, and bipolar disorder.
Most pediatric neurologists carefully monitor such interactions by frequent measurement of the levels of medication in the bloodstream; nonetheless, antiepilepsy drugs (AEDs) such as phenobarbital and clonazepam can cause side effects including irritability, sleepiness, or difficulty maintaining sleep.
* A new study published in the April 12, 2001, issue of The New England Journal of Medicine concludes that specific physical birth defects in babies of mothers with epilepsy are linked to the use of antiepilepsy drugs during pregnancy, rather than the epilepsy itself.
In adults felbamate has been shown to be effective when given alone or in combination with other antiepilepsy drugs. The new drug has also been found safe and effective when added to other antiepilepsy drugs in children 2 years and older who are suffering from Lennox-Gastaut syndrome.
Results from prior studies by other investigators documented that the hepatic enzymes induced by the older antiepilepsy drugs speed the metabolism of statins and blunt their effect.
The mean number of seizures during the prior year was 4.3, and patients were taking an average of 1.7 antiepilepsy drugs.