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References in periodicals archive ?
Carotenoids activate the antioxidant response element transcription system.
The KeratinoSens[TM] cell line contains a stable insertion of a luciferase gene under the transcriptional control of a constitutive promoter fused with the ARE (Antioxidant Response Element) from the AKR1C2 gene (Lou et al., 2006).
Khanderao et al., "Sustained activation of nuclear erythroid 2-related factor 2/ antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice," Antioxidants & Redox Signaling, vol.
The Nrf2 antioxidant response element pathway-mediated neuroprotection has been shown in animal models mimicking certain aspects of glaucoma pathology.
Pickett, "Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2," Proceedings of the National Academy of Sciences of the USA, vol.
Increased protein stability as a mechanism that enhances Nrf2mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome.
Measurement of Antioxidant Response Element (ARE) Activity Assay.
QHTS Assay for Small Molecule Agonists of the Antioxidant Response Element (ARE) Signaling Pathway.
Abbreviations: ARE, antioxidant response element; CAA, cell-based antioxidant activity; GTP-CH1, GTP-cyclohydrolase I; IDO, indoleamine 2,3-dioxygenase; IL-2.
This review focuses on the therapeutic promise of dihydroquercetin in major disease states such as cancer, cardiovascular disease and liver disease by reviewing the proposed mechanism(s) of action, including the activation of the antioxidant response element (ARE) and detoxifying phase II enzymes, inhibition of cytochrome P(450) and fatty acid synthase in carcinogenesis.
Antioxidant Products: Pomegranate, 40% ellagic acid; apple, 50% polyphenols; raspberry, 4% ellagic acid; maitake, 30% polyphenols; cili, 20% vitamin C; rosemary, 10% carnisic acid; sage, 20:1 extract; broccoli extract (activates antioxidant response element of DNA in cells to up-regulate cells' own antioxidants); green tea, 95% polyphenols; wolfberry, 20% polyphenols
A recent study indicates lycopene may recruit the body's natural cancer-fighting ability by stimulating an "antioxidant response element." This mechanism is so important the FDA is reviewing the clinical data and scheduled to announce its decision this month for allowing a health claim for men's prostate health.