(redirected from Antiretroviral therapy)
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ARVTAntiretroviral Therapy (HIV/AIDS prevention and treatment)
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The study also determined who took antiretroviral therapy for at least 6 months.
Compared with the antiretroviral therapy which needs to be taken daily, antibodies to HIV tend to last longer in the body and have shown promise for longer-acting HIV therapeutics and prevention modalities, they noted.
These oral lesions are strongly associated to low CD4+ count and high viral load.2 Antiretroviral therapy is given to HIV/AIDS patients that usually consists of two nucleoside reverse transcriptase inhibitors (NRTI) alongwith non-nucleoside reverse transcriptase inhibitor (NNRTI) or protease inhibitor (PI).3 Antiretroviral therapy reduces the viral load by inhibiting the viral replication and results in the reconstitution of the immune system alongwith the increase in CD4+ lymphocyte count.4 Frequency of oral lesions has been reported to be decreased after antiretroviral therapy (ART) especially in case of oral candidiasis, oral hairy leukoplakia, necrotizing periodontal conditions and various AIDS related malignancies like Kaposi sarcoma.5
To address this knowledge gap, researchers in the International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) designed and conducted the Strategic Timing of Antiretroviral Therapy (START) trial, which compared the benefits and risks of immediate initiation of antiretroviral therapy in patients with CD4+ counts above 500 cells/cc (2,326 patients) against deferring therapy until CD4+ counts declined to 350 cells/cc (2,359 patients).
US study leader Anthony Fauci says: "We now have clear-cut proof that it is of significantly greater health benefit to a HIV-infected person to start antiretroviral therapy sooner rather than later.
A higher proportion of participants in the home group than in the facility group initiated antiretroviral therapy (2.2% vs.
According to the researchers, these findings, coupled with results from previous studies, suggest that treating certain HIV-infected people with a combination of antiretrovirals and an immunotoxin might help achieve sustained disease remission, in which HIV can be controlled or eliminated without a lifetime of antiretroviral therapy. However, further study is required, the scientists write.
The new WHO guidelines also recommend providing antiretroviral therapy to all children younger than 5, all pregnant and breastfeeding women with HIV, and all HIV-positive patients with partners who are not infected, regardless of a person's T-cell count.
"With smart planning, we estimate that cost savings of around 20% could be made by 2015 which, if invested smartly, would allow us to reach yet more people with lifesaving antiretroviral therapy."
Investigators wanted to get a clearer understanding of the impact of starting antiretroviral therapy on the risk of TB.
Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy. Curr HIV/AIDS Rep 2007; 4: 16-21.
With the rapid scaleup of antiretroviral therapy in India both in the public and private sectors, more patients are benefited.