AoCLFAcute-on-Chronic Liver Failure
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The most common use of MARS occurs in AoCLF patients when the patient decompensates either due to alcohol use, bleeding, or an infection.
However, with AoCLF, time to treatment is difficult to determine and it may be comparably effective to have intermittent treatments lasting only six to eight hours instead of continuous therapy.
Patients in ALF are more tolerant of a higher INR than are AoCLF patients (Mitzner) and, thus, are at less risk of an adverse bleeding event.