APOB


Also found in: Medical, Encyclopedia.
AcronymDefinition
APOBApolipoprotein B
APOBArchitects and Planners of Boulder (Colorado)
APOBAmericans for the Preservation of Bail
Copyright 1988-2018 AcronymFinder.com, All rights reserved.
References in periodicals archive ?
They developed genetic scores, which researchers use to understand how genetic variations affect risk, and looked at how those scores were related to CHD risk per unit of lowered APOB. They found that each 10-milligram/deciliter (mg/dL) reduction of APOB resulted in a similar lower risk of CHD--regardless of whether it came from triglyceride or cholesterol reduction.
In this context, it was hypothesized that the significant changes in the lipid profile are related to polymorphisms of the ApoB gene (rs1042031 and rs693), and the improvement of the aerobic functional capacity is associated with the ACE I-allele in patients with CAD and/or cardiovascular risk factors submitted to the AIT program.
These tests (apoB and hs-CRP) give a much better assessment of heart attack risk than a standard lipid profile alone.
Despite accumulating evidence in favor of apoB, guidelines continue to focus solely on LDL-C.
The mechanism by which raised apoB and TG levels in combination increase the risk of CHD is yet uncertain.
Discordance analysis and the Gordian Knot of LDL and non-HDL cholesterol versus apoB. Curr Opin Lipidol.
The association between saturated fat and fewer CV events was related to the simulated association mediated by the effects on the ApoB / ApoA1 ratio, but not with other lipid markers, including LDL-cholesterol.
The effect of SNP variants in the protein functionality of genes listed above was determined using Ensembl Variant Effect Predictor, resulting in that two SNPs found in ATM and APOB can induce deleterious amino acid changes, while others were tolerated mutations (data not shown).
An estimated 70%-95% of FH results from a heterozygous pathogenic variant in one of three genes (APOB, LDLR, PCSK9).
Apolipoprotein B (apoB) represents the total number of apoB-containing lipoproteins [7] and is considered to be superior to LDL-C and non-HDL-C in predicting cardiovascular disease [8], whereas apolipoprotein A-I (apoA-I) has a known inverse association and low levels are associated with increased body mass index (BMI) [9].
Now, a meta-analysis suggests that oats can also reduce two other markers of cardiovascular disease: non-HDL cholesterol (total cholesterol minus the "good" HDL cholesterol), and apolipo-protein B (apoB), a substance that carries LDL cholesterol through the blood.