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References in periodicals archive ?
Aristolochic acid I (A5512), rosiglitazone (R2408), and 2',7'-dichlorofluorescein (DCF) diacetate (DCFDA) (D6883) were obtained from Sigma.
Thus, aristolochic acid I (118) shown 397 of 3300, and aristolochic acid II (119) shown 762 of 3300 possible activities at [P.sub.a] > [P.sub.i], and in supplementary Table 6 shows only the 40 most probable activities.
Yu, "Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK1/2 pathway in renal tubular epithelial cells," PLoS ONE, vol.
The herb contains aristolochic acid I (AA-I), which has recently caused several incidents of poisoning in Hong Kong.
Keywords: Aristolochic acid I; Herba Asari; Asarum: Aristolochia; Liquid chromatography--mass spectrometry
ND AAI, AAII: aristolochic acid I and II; ND*: not detectable or negative; **not tested; ([dagger]): independent contracting laboratory sites I, II, III and IV; a: range of detectable levels by HPLC-MS or GC-MS in unit expressed as mgAA/g herb; b: level measured by laboratory site III were by part per million (ppm) or laboratory site IV as detectable (([dagger][dagger]): +) or nondetectable (-).
Many studies since have confirmed that aristolochic acid is a nephrotoxic drug and a human carcinogen that can cause progressive renal interstitial fibrosis and urothelial carcinoma.[sup][4] The patient exhibited low specific gravity urine and urine acidification function impairment, and these presentations of renal pathology were also consistent with the pathological changes in aristolochic acid nephropathy.[sup][5] Therefore, the possibility of renal tubular disease caused by drug-related damage should be considered.
The aristolochic acid is a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments like arthritis, gout and inflammation.
For example, aristolochic acid is not produced in the United States and the federal government has in place an import ban on it.
For example, she said, aristolochic acid is not produced in the United States and the federal government has an import ban on it, so if the law were being enforced it would not be available for sale here.
Washington, Dec 22 (ANI): The consumption of popular Chinese herbal products containing carcinogen aristolochic acid is linked to an increased risk of urinary tract cancer, a new study has found.