ASC-US

(redirected from Atypical Squamous Cells of Undetermined Significance)
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AcronymDefinition
ASC-USAtypical Squamous Cells of Undetermined Significance (pap smear)
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Outcomes in women with cytology showing atypical squamous cells of undetermined significance with vs without human papillomavirus testing.
TABLE USPSTF cervical cancer screening recommendations (2) Age (years) Recommendation <21 No screening 21-29 Screen with cytology every 3 years, with reflex HPV testing if ASCUS is detected 30-65 Screen with a combination of cytology and HPV testing every 5 years (cytology every 3 years is an acceptable option) >65 Discontinue screening ASCUS, atypical squamous cells of undetermined significance; HPV, human papillomavirus; USPSTF, US Preventive Services Task Force.
The application of immunocytochemical and/or immunohistochemical analysis with an antibody to p16INK4a can help to differentiate lesions which are citologically interpreted as atypical squamous cells of undetermined significance or atypical squamous cells and histologically interpreted as preneoplastic lesions (CIN 1, CIN 2).
Atypical squamous cells of undetermined significance in patients with HPV positive DNA testing and correlation with disease progression by age group: an institutional experience.
Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. Am J Obstet Gynecol 2003; 188(6): 1383-1392.
Restraint is also warranted in the management of teens whose Pap tests show atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL), Dr.
Prevalence of squamous intraepithelial lesion (SIL) and malignancy for atypical squamous cells of undetermined significance (ASC-US) in a public health service in Colombia, 2004-2005
Clinical Acronyms Atypical glandular cells AGC Atypical glandular cells not otherwise specified AGC-NOS Adenocarcinoma in situ AIS Atypical squamous cells ASC Atypical squamous cells: cannot exclude high-grade ASC-H Atypical squamous cells of undetermined significance ASC-US Cervical intraepithelial neoplasia CIN High-grade squamous epithelial neoplasia HGSIL Human papillomavirus HPV Low-grade squamous intraepithelial lesion LGSIL
Results of a randomized trial on the management of cytology interpretation of atypical squamous cells of undetermined significance. Am J Obstet Gynecol 2003; 188 : 1383-92.
HPV16 was the most common type in the 2,053 women with atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions.
Among 18-year-olds with Pap smears classified as atypical squamous cells of undetermined significance (ASCUS), 71% will be positive for high-risk HPV and two-thirds will continue to be abnormal on a repeat Pap smear.
Four were classified as atypical squamous cells of undetermined significance, two in the HPV-positive group and two in the HPV-negative group.
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