Discovered by Eisai, elenbecestat is an investigational next-generation oral candidate for the treatment of Alzheimer's disease (AD) that inhibits BACE
(beta amyloid cleaving enzyme).
Characteristics of older patients with back pain in general practice: BACE
The A45 study will be a global, multicenter, double-blinded, placebo-controlled, randomized trial of a treatment regimen consisting of an anti-A[beta] antibody and a BACE
inhibitor to prevent cognitive decline and delay biomarkers of pathological progression versus placebo.
In addition, the safety of the new BACE
drugs has been a subject of concern since Lilly pulled the plug on its product due to liver toxicity.
has proved to be a difficult enzyme to block, despite lots of efforts by drug companies.
At Madison, N.J.-based wealth management firm Brinton Eaton, Principal Marla Bace
says the firm has created a LinkedIn profile for each of its advisors, allowing people who may view those profiles "to get a feeling for what that person is like as an individual." Then, if those advisors participate in "a conversation chain with consumers or peers, we strictly provide educational answers to their inquiries.
"We now know much better how Beta secretase works because we have found that the 12/15-Lipoxygenase protein is a controller of BACE
functions," he said.
Adapting themes from Wolburg's (2001) analysis of students' motivations for binge drinking, Crawford and Novak (2006) constructed a measure of beliefs about alcohol and the college experience (BACE
) that captures these two aspects of student drinking: the extent to which college undergraduates perceive themselves as occupying a unique, albeit temporary, status that enables them to drink irresponsibly with few negative consequences; and the degree to which they embrace the transformative effects of alcohol on their social interactions.
They found that PGC-1 promotes degradation of a specific enzyme known as beta-secretase (BACE
The court's decision highlights the need for clear and current privacy policies, according to John Bace
, research vice president at analyst firm Gartner, Inc.
Through the Federal Rules of Civil Procedure (FRCP), businesses of any size are required to provide all electronic records related to a suit or face draconian sanctions as opined by John Bace
, research vice president at Gartner, Inc.