Associations between variants in KITLG, SPRY4, BAK1
, and DMRT1 and pediatric germ cell tumors.
Ross, "Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors," Genes Chromosomes and Cancer, vol.
Vaux, "BCL2 and related pro-survival proteins require BAK1 and BAX to affect autophagy," Autophagy, vol.
Shi, "miR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1
," Tumor Biology, vol.
, Bcl-xL, CASPASE3, and TP53 are known regulators of apoptosis, and are related to the intrinsic mitochondrial apoptosis pathway.
To further test this finding, we evaluated the gene expression levels of all four apoptosis signaling-related genes predicted to be targeted by miR-125b, namely BAK1
, CASP2, MAP2K7, and MCL1.
nucleatum Regulation of (normalized (normalized expression (fold of gene expression) expression) control) CTSS 0.02147 0.09855 4.59035 PIK3CG 0.00001 0.00004 4.03971 DRAM1 0.74956 1.92932 2.57393 IGF1 0.01431 0.03249 2.27069 NFKB1 0.40746 0.85589 2.10054 BID 0.14601 0.30644 2.09878 BAK1
0.01303 0.02353 1.80636 TNFSF10 0.00721 0.01299 1.80182 INS 0.00960 0.01558 1.62314 TMEM74 0.01275 0.01934 1.51678
TDF72 encodes a BRI1-associated receptor kinase 1 (BAK1
), a second LRR RLK that interacts with BRI1 in vitro, and may play an important role in BR signal transduction [64, 65].
The proapoptotic protein Bak1
is a target to miR-125b, and interestingly, this protein has been shown to be decreased in hormone-refractory tumors (69).
The most significantly linked marker was identified as BAK1
on BTA23 (Everts-van der Wind et al., 2004).
miR-125b, an androgen-sensitive miRNA in prostate cancer, has been reported to stimulate androgen-independent growth and to regulate apoptosis by inhibition of BAK1
[encoded by BCL2-antagonist/killer 1 (BAK1
Genes with decreased expression in the cells included the proapoptotic gene BAK1
and the cell cycle control gene p15INK4B.