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Group 2 (BAPN) had the minimum HDS value compared with the other corrosive burn groups (Control and Prednisolone).
The results indicate that BAPN treatment significantly reduced the HDS while prednisolone treatment did not.
Also, the results demonstrated that BAPN treatment reduced the SI better than prednisolone treatment in corrosive burn groups although did not significantly.
BAPN leads to lathyrism by inhibiting lysyl oxidase, which is an important enzyme in the synthesis of collagen and elastin.
In a study conducted on scar formation in colon anastomoses and the effects of iatrogenic medications, it was demonstrated that the local and systemic use of BAPN reduces postoperative intra-abdominal adhesions and significantly reduces the thickness of granulation tissue .
BAPN alone, without addition of mechanical bougienage, is as effective in preventing esophageal stenosis as large doses of systemic steroid hormones and biweekly bougienage.
In contrast, treating with bougienage and BAPN produced a significant increase in esophageal diameter and restored normal deglutition .
In our study, it has been demonstrated that BAPN reduced HDS and SI better than prednisolone in rats with corrosive esophageal burns.
The results also indicate that BAPN treatment significantly reduced the HDS while prednisolone treatment did not.
In our study, HDS in terms of the role of prevention of the fibrosis development of the group being treated by administrating BAPN was lower compared to the group in which prednisolone was administrated.
It has been shown that the healing effect of BAPN on corrosive esophageal burns in terms of histological assessment was meaningful in this study.
It has been demonstrated that BAPN reduced HDS and SI in rats with corrosive esophageal burns.
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- Baphalali Swaziland Red Cross Society
- Baphia nitida
- Baphia nitida