Common variations in BARD1
influence susceptibility to high-risk neuroblastoma.
Ulz et al., "Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1
and TP53 in patients with therapy related myeloid neoplasms," Journal of Medical Genetics, vol.
It interacts with the BRCA1-associated RING finger domain protein (BARD1
) (Jensen et al., 1998) which is required for ubiquitin ligase activity, the MRE11/RAD50/NBS1 (M/R/N) recombination repair complex, a putative DNA helicase BRCA1-associated C-terminal Helicase (BACH1) (Cantor et al., 2001), the CtBp-interacting protein CtIP (Kaelin et al., 1990) and RNA polymerase II (Scully et al., 2000).
IN THEIR ELEMENT: CTC carrying out cable installation work on the BARD1
Offshore Wind Farm
CTC is currently mobilising for its return in April to the BARD1
project, the first commercial scale wind farm in Germany.
The researchers have also found gene called BARD1
, six single-nucleotide polymorphisms - variations in tiny pieces of DNA - were also associated with neuroblastoma.
Cys557Ser variant and breast cancer risk in Iceland.
BRCA-1, for example, interacts with a partner protein known as BARD1
(BRCA-1-associated ring domain).
Robust examples from the multiple case-control association studies of common variants include a missense arginine to histidine amino acid change (D302H) in CASP8 associated with a moderate reduction in breast cancer risk , a common amino acid change (C557S) in BARD1
which increased breast cancer risk , and most recently a variant in RASSF1A associated with early-onset cancer in BRCA1 and BRCA2 mutation carriers .