BCCAOBilateral Common Carotid Artery Occlusion
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In the bilateral ICA occlusion model, the blood flow insufficiency is milder than that after the BCCAO, which is closer to the clinical situation of OIS.
rCBF was tested before and after BCCAO (within 30 min) andbefore killing by laser Doppler flowmetry (PeriFLUX5000, Sweden) including the following steps.
rCBF before/after BCCAO. The rCBF of pre-BCCAO did not show any significant difference between the sham and operation group (P > 0.05), while there was significant decrease (P < 0.01) in operation group after BCCAO, as shown in Table 3.
Results showed that 4 weeks after BCCAO, expression of JAK2 and STAT3 mRNA enhanced in model and EA group, particularly in the former; there was significant difference between sham group and model group (P < 0.05).
Detecting the cerebral blood flow in SD rats of the BCCAO model revealed that the blood flow in the brain cortex and hippocampus significantly decreased 2.5 h after ischemia.
Of course, until now, only initial conclusions have been drawn and we will do further research upon the following goals: firstly, classical CCI model was evaluated by the water maze and pathological section in 3-6 weeks after BCCAO operation and this study emphasizes intervention in early stages.
Results: BCCAo increased glial proliferation in the hippocampus and white matter, whereas proliferation was significantly attenuated by GBE treatment.
We induced permanent bilateral common carotid artery occlusion (BCCAo) in rats to establish a CCH model, which is a widely used preclinical model for VaD therapeutic screening (Kwon et al., 2014).
Rats were anesthetized with 5% isoflurane in a mixture of 30% oxygen/70% nitrogen and a modified BCCAo surgery was performed (Choi et al., 2011).
All the rats were randomly assigned to 1 of 6 treatment groups: (1) sham-operated + saline (n = 12), (2) BCCAo + saline (n = 12), (3) BCCAo + GBE 5mg/kg (n = 12), (4) BCCAo + GBE 10 mg/kg (n = 12), (5) BCCAo + GBE 20 mg/kg (n = 12), or (6) BCCAo + GBE 40 mg/kg (n = 12).
A common feature of the BCCAo rat model is glial (microglia and astrocytes) proliferation (Bang et al., 2013; Cai et al..
BCCAO resulted in severely reduced thickness of retinal layers as observed two weeks after ligation compared to sham-operated controls (Figure 1(a)).