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In cellular and mouse studies, senior author Mien-Chie Hung and his colleagues found that the gene mutation BikDD significantly reduced treatment-resistant breast-cancer initiating cells (BCICs), also known as breast cancer stem cells, by blocking the activity of three proteins in the Bcl-2 family.
"There are no effective methods to target BCICs, and they're urgently needed, especially for relapsed breast cancer patients," said Hung, Ph.D., vice president for basic research, professor and chair of MD Anderson's Department of Molecular and Cellular Oncology.
Peredo is also the Interim Director for the BC Research Institute for Co-operative Studies (BCICS) at the University of Victoria.