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32) In addition to CD10, BCL2, an antiapoptotic protein, is useful in differentiating FL from reactive follicular hyperplasia, but expression of BCL2 depends on grade and location.
Conclusions: Dioscin inhibited tumor growth via inducing apoptosis, which was accompanied by altered expression of apoptotic pathway proteins, such as TP53, BAX, BCL2 and CASP3.
miR- 15 and miR-16 induce apoptosis by targeting BCL2.
Detection of BCL2 Rearrangements in Follicular Lymphoma.
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Gene EphB2 impairs tumor suppression and gene BCL2 causes premature cell death.
La translocacion t(14; 18) genera la expresion de la proteina antiapoptotica BCL2 que se encuentra en el centrogerminal y en pacientes tratados con rituximab se asocia con mal pronostico en el fenotipo GCB a diferencia del ABC (9).
PNT2258 utilizes a proprietary DNA interference technology to block a key oncogene BCL2 that then signals cancer cells to die.
Immunophenotyping is essential and can be very helpful (the neoplastic B cells of BL are typically CD10 positive and BCL2 negative) but variant immunophenotype can be seen in BL.
Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis.
Jamieson and colleagues found that alternative splicing of BCL2 genes, which code for proteins involved in apoptosis or programmed cell death, specifically promoted malignant transformation of dormant white blood cell precursors into "blast crisis" LSCs.