Hey1, gen diana representativo de la via de senalizacion celular Notch, codifica para un factor de transcripcion Basic helix-loop-helix (bHLH
), con capacidad para unirse a sitios especificos de los promotores, inhibiendo asi, la transcripcion de ciertos genes diana e inclusive de ellos mismos (9).
Phylogenetics of lophotrochozoan bHLH
genes and the evolution of lineage-specific gene duplicates.
Azad et al., "Analysis of Polymorphism rs1900004 in Atonal bHLH
Transcription Factor 7 in Saudi Patients with Primary Open Angle Glaucoma," Genetic Testing and Molecular Biomarkers, vol.
In the drought-stressed hemp, 51 DEGs of families including bHLH
, MYB, NAC, WRKY, and AP2/ERF were identified.
RSA1, a nuclear-localized calcium-binding protein, its interacting partner, RITF1, and a transcription factor bHLH
are involved in the regulation of salt stress by hunting reactive oxygen species (ROS) and regulating SOS1 gene (Guan et al., 2013).
Ohtsuka et al., "Oscillatory expression of the BHLH
factor Hes1 regulated by a negative feedback loop," Science, vol.
For example, most bHLH
, WRKY, and ERF-encoding genes showed higher transcript level in the roots of G.935, but a majority or all of identified MYB and NAC encoding DEGs showed opposite patterns with higher transcript level in the roots of B.9.
In addition, transcription factors that play important role in EMT, such as twist family BHLH
transcription factor-1 (TWIST-1), zinc finger E-box binding homeobox-1 (ZEB-1)/ZEB-2, and snail family transcriptional repressor1 (SNAIL-1)/SNAIL-2, were found to be altered in GBM [38, 39] as the proneural cells undergo transformation to mesenchymal subtype.
Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH
gene expression in the somite.
(12,13) The EMT has been well described in a number of biologic paradigms, including embryogenesis, tissue fibrosis, and cancer, and is initiated through upregulation of SNAIL, zinc-finger E-box binding (ZEB), and basic helix-loop-helix (bHLH
) transcription factors.
protein, MUTE, controls differentiation of stomata and the
In gene regulation, transcription factors such as basic leucine zipper (bZIP) (Yang et al., 2009), WRKY (Jiang and Deyholos, 2009), Apetala2/ETHYLENE RESPONSE FACTOR (AP2/ERF) (Kasuga et al., 1999), MYB (Cui et al., 2013), basic helix- loop-helix (bHLH
) (Jiang et al., 2009) and NAC (Tran et al., 2004) regulate the expression levels of various genes that ultimately influence salt tolerance of plants.